Abcam, ab197076, Anti-TTC28/TPRBK antibody - C-terminal

Size: 100µL
Rabbit Polyclonal TTC28/TPRBK antibody. C-terminal. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TTC28 aa 2450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TTC28 aa 2450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96AY4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab197076 was affinity purified using an epitope specific to TTC28/TPRBK immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TTC28 also known as TPRBK is a protein with a molecular weight of approximately 230 kDa. This protein consists of tetratricopeptide repeat domains that are important for protein-protein interactions. TTC28 exhibits a broad expression pattern in human tissues but shows higher expression levels in the brain testis and certain cancerous tissues. Its widespread expression suggests a fundamental role across various biological systems.
Biological function summary
TTC28/TPRBK may influence cellular processes including cell cycle regulation and protein folding. This protein interacts with other proteins as part of a multiprotein complex including components of the cytoskeleton and cell cycle regulators. Its participation in these important processes suggests that TTC28 plays a role in maintaining cellular integrity and function.
Pathways
When considering the cellular mechanism TTC28/TPRBK participates in the cell cycle regulation pathway and possibly impacts cell division. It shows interaction with proteins like cyclins and cyclin-dependent kinases which are central to the progression of the cell cycle. These associations indicate that TTC28's function in pathways reflects its functional importance in regulating proper cellular division and growth.
Researchers associate TTC28/TPRBK with specific types of cancer such as glioblastoma and breast cancer. Aberrant expression or dysfunction of TTC28 may disrupt normal cell cycle progression leading to uncontrolled cell proliferation. Its interaction with oncoproteins such as Cyclin D1 further corroborates its potential role in oncogenesis. Understanding TTC28's involvement in these diseases can contribute to developing targeted therapeutic strategies.