Abcam, ab197083, Anti-UBAP2 antibody

Size: 100µL
Rabbit Polyclonal UBAP2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human UBAP2 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBAP2 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q5T6F2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab197083 was affinity purified using an epitope specific to UBAP2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBAP2 also known as Ubiquitin-Associated Protein 2 plays a role in cellular processes by interacting with ubiquitin-related pathways. It has a mass of approximately 115 kDa. This protein functions mainly in the cytoplasm but is also present in the nucleus in certain cell types. UBAP2 expression occurs in a wide range of tissues with higher levels observed in immune cells such as lymphocytes.
Biological function summary
UBAP2 interacts with components of the endosomal sorting complex required for transport (ESCRT) machinery. This interaction suggests a role in vesicle trafficking and membrane dynamics. UBAP2 has not been reported as part of a complex but might work closely with other ubiquitin-interacting proteins to regulate endocytic processes. It may assist in sorting endocytosed proteins for degradation or recycling.
Pathways
UBAP2 takes part in ubiquitin-mediated processes and is linked to the intracellular trafficking pathway. Its interaction with the ESCRT machinery indicates participation in endosomal and lysosomal pathways. Related proteins include ubiquitin and TSG101 which are involved in coordinating the sorting and transport of proteins through the endosomal system.
Researchers investigate UBAP2 for its potential link to neurodegenerative diseases such as Alzheimer's disease and certain cancers. Studies propose that altered ubiquitin pathways may contribute to these conditions implicating proteins like TSG101. Alterations in UBAP2 function might therefore disrupt normal cellular processes contributing to disease progression and pathology.