Abcam, ab197085, Anti-LARP4B antibody

Size: 100µL
Rabbit Polyclonal LARP4B antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human LARP4B aa 600-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LARP4B aa 600-650. The exact immunogen used to generate this antibody is proprietary information.Q92615

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab197085 was affinity purified using an epitope specific to LARP4B immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LARP4B also known as La-related protein 4B is a protein of approximately 78 kDa. It is expressed in various tissues but shows higher expression in testis and liver. The protein contains an RNA-binding domain which indicates its role in RNA metabolism. LARP4B interacts with mRNA influencing its stability and translation. This protein belongs to the LARP family which is known for involvement in RNA-binding processes.
Biological function summary
LARP4B plays a role in regulating mRNA stability and translation. It often cooperates with mRNA decay and translation initiation factors. LARP4B does not form a stable complex but associates transiently with other RNA-binding proteins to perform its function. Its ability to bind mRNA suggests involvement in gene expression post-transcriptionally impacting various cellular processes.
Pathways
LARP4B is implicated in the mTOR signaling pathway and the RNA processing pathway. The mTOR pathway is essential for cell growth and proliferation linking nutrient availability to these processes. LARP4B works in tandem with other proteins like LARP1 and EIF4E to modulate mRNA stability indirectly influencing cell growth through translation regulation.
LARP4B has a connection to cancer and neurological disorders. Abnormal expression of LARP4B has been observed in certain cancers suggesting a role in tumorigenesis. In neurological disorders differences in LARP4B expression levels have been associated with disease progression. The protein establishes a relationship with LARP1 in cancer contexts further exploring how altered mRNA translation contributes to these diseases.