Abcam, ab197123, Anti-GINS2 antibody

Size: 100µg
Rabbit Polyclonal GINS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GINS2 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GINS2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y248

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GINS2 protein also known as PSF2 is a part of the GINS complex essential for DNA replication initiation and synthesis. It has a mass of approximately 21 kilodaltons. This protein is expressed in various tissues particularly in those with high proliferative capacity such as the thymus and testis. GINS2 plays a fundamental role in the assembly of the pre-replication complex working alongside other core replication factors.
Biological function summary
GINS2 functions as a part of the tetrameric GINS complex which includes the proteins GINS1 (Sld5) GINS3 (Psf3) and GINS4 (Psf1). This complex is indispensable for the progression of the DNA replication fork and interacts with other replication machinery components like CDC45 and Mcm proteins. The collaboration of these proteins ensures successful DNA unwinding and synthesis demonstrating the critical role of GINS2 in cell proliferation and genomic stability.
Pathways
GINS2 is important in the DNA replication pathway and the cell cycle control mechanism. It closely interacts with proteins like CDC45 and Mcm2-7 facilitating the replication fork formation and movement during the S phase of the cell cycle. These interactions integrate GINS2 into the larger network that orchestrates DNA replication ensuring precise duplication of the genome before cell division.
GINS2 shows a connection to cancer and genomic instability disorders. Overexpression or dysfunction of GINS2 can result in unregulated cell proliferation a characteristic often observed in various cancers. The protein associates with the Mcm complex and CDC45 contributing to unwarranted cell cycle progression and tumor development. Understanding the GINS2 role in these conditions highlights its potential as a target for therapeutic interventions.