Abcam, ab197987, Anti-GilZ / TilZ antibody

Size: 100µL
Rabbit Polyclonal GilZ / TilZ antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TSC22D3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TSC22D3.Q99576

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GilZ also known as glucocorticoid-induced leucine zipper is a protein with a mass of approximately 14 kDa. This protein acts mechanically as a transcriptional regulator and plays an important role in modulating immune cell functions. GilZ is widely expressed especially in lymphoid tissues and in cells involved in the immune response. It is also expressed in various other tissues including the brain and liver where it contributes to different cellular processes. This protein is linked to the suppression of certain inflammatory responses mediated by its interactions with key transcription factors.
Biological function summary
GilZ influences immune cell proliferation and differentiation impacting how the body responds to inflammation. It frequently forms complexes with other proteins to perform its functions. GilZ serves as a mediator of glucocorticoid actions which affects the expression of cytokines and other inflammatory mediators. Through its interactions with components of the immune system GilZ plays an important role in maintaining homeostasis under stress conditions such as during an inflammatory response or cell damage.
Pathways
The glucocorticoid pathway is central to the activities of GilZ. This pathway involves a complex network where GilZ interacts with proteins such as the NF-kB which is another transcription factor involved in the inflammatory response. GilZ affects this pathway by inhibiting the activity of NF-kB leading to decreased expression of pro-inflammatory cytokines. Additionally GilZ is involved in the T-cell receptor (TCR) signaling pathway where it modulates T-cell activation and survival affecting immune system regulation.
GilZ is relevant to conditions characterized by chronic inflammation such as rheumatoid arthritis and asthma. In these diseases the protein's ability to downregulate inflammation makes it a potential target for therapeutic intervention. GilZ influences the expression and activity of proteins like cytokines which are heavily involved in the inflammatory pathways of these diseases. Understanding the role of GilZ in these contexts could aid in designing more effective treatments for inflammatory conditions.