Abcam, ab198196, Anti-NDUFA2 antibody

Size: 100µL
Rabbit Polyclonal NDUFA2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NDUFA2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NDUFA2.O43678

Product details:
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NDUFA2 protein also known as NADH:Ubiquinone Oxidoreductase Subunit A2 is a component of the mitochondrial respiratory chain complex I. It has a mass of approximately 10.3 kDa. NDUFA2 is expressed in various tissues with high energy demands especially in the heart brain and skeletal muscles. Functionally it participates in the initial phase of electron transport by transferring electrons from NADH to ubiquinone contributing to the proton gradient used in ATP synthesis.
Biological function summary
NDUFA2 is a component of the multi-subunit complex I of the mitochondrial electron transport chain. This complex plays a role in cellular respiration by facilitating the conversion of energy stored in nutrients into ATP. Within the structure of complex I NDUFA2 collaborates with other subunits to ensure efficient electron transfer processes. Although a smaller subunit its role in the proper assembly and maintenance of the complex is essential for sustaining cellular energy levels.
Pathways
The actions of NDUFA2 are critical in oxidative phosphorylation one of the main pathways for ATP production in eukaryotic cells. This energy production pathway is intertwined with cellular respiration where NDUFA2 is related to proteins such as ND1 and ND2. These proteins collectively engage in the transfer of electrons across the inner mitochondrial membrane driving the synthesis of ATP from ADP through chemiosmotic coupling.
Alterations in NDUFA2 have connections to mitochondrial encephalomyopathy and Leigh Syndrome. These conditions manifest due to dysfunctional energy metabolism caused by defects in NDUFA2 and other proteins like NDUFS1. Mutations in these proteins can lead to impaired oxidative phosphorylation resulting in energy deficiencies that contribute to the development of neurodegenerative and muscular impairments seen in these disorders.