Abcam, ab19867, Anti-MEIS1 antibody

Size: 100µg
Anti-MEIS1 antibody (ab19867) is a rabbit polyclonal antibody detecting MEIS1 in Western Blot, IHC-P . Suitable for Human, Rat . - Over 30 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Mar 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Product details:
What is this antibody validated in?
Anti-MEIS1 antibody (ab19867) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Rat samples.
What is the molecular weight of MEIS1?
Anti-MEIS1 (ab19867) specifically detects a band for MEIS1 (UniProt: O00470) at a molecular weight of 43, 50kDa.
Trusted by the scientific community
Anti-MEIS1 (ab19867) was first used in a scientific publication in 2006 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEIS1 known as myeloid ecotropic viral integration site 1 is a homeobox protein that functions as a transcription factor. MEIS1 has a molecular mass of approximately 48 kDa. This protein is expressed in various tissues with high levels noted in the hematopoietic system particularly in progenitor cells. Its role in niave to the human developmental system is well detailed showing influence in developmental processes through gene expression regulation.
Biological function summary
As part of a protein complex MEIS1 interacts with other transcription factors including PBX1 and HOXA9 to modulate target gene expression. MEIS1 plays a critical role in hematopoiesis influencing the development and maintenance of hematopoietic stem and progenitor cells. Also it contributes to limb development and the formation of the heart during embryogenesis. MEIS1’s role in cellular differentiation and organogenesis highlights its significance in developmental biology.
Pathways
MEIS1 acts within the RA (Retinoic Acid) signaling pathway and is also linked to the Wnt signaling pathway. Through these pathways MEIS1 collaborates with other proteins like PBX1 which assist in the regulation of gene expression critical for proper cell fate determination. In the RA pathway MEIS1 modulates the transcription of genes necessary for cell differentiation and proliferation. These pathways demonstrate the broad regulatory influence of MEIS1 on cellular processes.
MEIS1 is linked with an increased risk for restless legs syndrome (RLS) and certain types of leukemia. The interaction of MEIS1 with HOXA9 is notably relevant in the pathogenesis of leukemia as this partnership can cause dysregulation in gene expression leading to oncogenesis. Additionally genetic variations near MEIS1 have been correlated with susceptibility to RLS highlighting its role in neurological conditions. This underlines the clinical importance of MEIS1 in both hematological and neurological disorders.