Abcam, ab199133, Anti-ANGPTL2/ARP2 antibody

Size: 100µL
Rabbit Polyclonal ANGPTL2/ARP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPTL2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANGPTL2. The exact immunogen used to generate this antibody is proprietary information.Q9UKU9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ANGPTL2 protein also known as angiopoietin-like 2 or ARP2 is a secreted glycoprotein involved in various physiological processes. It weighs approximately 56 kDa. ANGPTL2 is expressed in several tissues including the heart lungs and adipose tissues indicating its diverse regulatory roles in the body. Researchers have identified its ability to modulate both local and systemic actions which highlights its significance in health and disease.
Biological function summary
ANGPTL2 plays a role in regulating angiogenesis inflammation and metabolic pathways. It acts independently and is not considered part of a larger complex. The protein demonstrates the ability to stimulate endothelial cell migration and proliferation promoting new blood vessel formation. Furthermore ANGPTL2 influences inflammatory responses and lipid metabolism linking it to energy balance and homeostasis functions within the organism.
Pathways
ANGPTL2 is significant in both the angiogenesis and inflammatory signaling pathways. In angiogenesis it interacts with pathways related to vascular endothelial growth factor (VEGF) which plays a critical role in blood vessel formation. In inflammatory signaling ANGPTL2 links to the nuclear factor kappa B (NF-kB) pathway which is essential for regulating immune responses. These associations position ANGPTL2 as an important influencer in cardiovascular health and immune system regulation.
ANGPTL2 has associations with chronic inflammatory diseases and cancer. Studies have indicated high levels of this protein in conditions like rheumatoid arthritis contributing to persistent inflammation. Furthermore elevated ANGPTL2 expression links to various cancers influencing tumor growth and metastasis. Its activity has connections with proteins like IL-6 and VEGF which are involved in the inflammatory and angiogenic processes respectively marking ANGPTL2 as a potential target for therapeutic intervention.