Abcam, ab199425, Anti-SSX2IP antibody [EPR16979]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SSX2IP antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16979,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SSX2IP also known as ADIP or SSX2-interacting protein is a protein weighing approximately 73 kDa. It functions mechanically as a centrosomal protein interacting with proteins involved in centrosome duplication and spindle formation. SSX2IP shows expression in various tissues especially in dividing cells highlighting its role in cell cycle regulation. It interacts with proteins like CCDC155 (CEP155) during centrosome dynamics.
Biological function summary
SSX2IP facilitates the assembly of the mitotic spindle and the proper segregation of chromosomes during cell division. It is part of a complex where it collaborates with spindle assembly factors to ensure accurate cell division. By supporting centrosome integrity SSX2IP plays a necessary role in maintaining genomic stability and proper cell proliferation.
Pathways
Several elements such as cell cycle progression and the SPICE1-interacting pathway rely on SSX2IP. It participates in pathways that oversee centrosome duplication and spindle dynamics making it critical for mitotic progression. SSX2IP interacts with proteins like SPDYA and PLK1 which are key elements in cell cycle-related pathways ensuring the fidelity of cell division.
Abnormalities in SSX2IP expression or function may have connections to cancer and neurodevelopmental disorders. In oncology dysregulation of SSX2IP can affect centrosome function and contribute to chromosomal instability a hallmark of many cancers. Additionally its interaction with abnormal centrosomal proteins like ASPM links it to microcephaly affecting neural development. Therefore understanding SSX2IP offers valuable insights into both cancer biology and developmental anomalies.