Abcam, ab199850, Anti-THUMPD1 antibody

Size: 100µg
Rabbit Polyclonal THUMPD1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human THUMPD1 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human THUMPD1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NXG2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THUMPD1 also known as THUMP domain-containing protein 1 is a protein involved in RNA modification processes. The protein has a molecular mass of approximately 45 kDa. THUMPD1 expresses in various tissues with notable levels in the brain liver and testis. As an essential protein it plays a mechanical role in RNA processing and modification specifically within transfer RNAs.
Biological function summary
THUMPD1 is involved in the methylation of RNA molecules. It often functions as part of a larger protein complex collaborating with other proteins for accurate RNA modification. These modifications affect RNA stability and translation critical for regular cellular function. This active participation in RNA systems indicates a significant impact on maintaining protein homeostasis within cells.
Pathways
THUMPD1 has a role in important RNA-centric pathways. It connects with the tRNA methylation pathway and is associated closely with the RNA processing pathway. Proteins like TRMT1 and NOP2 relate to THUMPD1 within these pathways sharing the common function of ensuring correct RNA modifications. This connectivity positions THUMPD1 as a significant participant in genetic regulation activities.
THUMPD1 links to several genetic conditions with defects in RNA modification pathways. Research highlights connections to specific cancers such as liver cancer where dysregulation of RNA methylation is observed. Additionally THUMPD1 may influence neurological disorders through related pathways. Interactions with proteins such as METTL3 further suggest its involvement in these conditions where changes in RNA processing are a factor.