Abcam, ab200039, Anti-TMC2 antibody [EPR19446]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TMC2 antibody. Suitable for WB, ICC/IF, IHC - Wmt, Flow Cyt (Intra) and reacts with Transfected cell lysate - Mouse, Mouse, Transfected cell line - Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19446,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, ICC/IF, Flow Cyt (Intra), IHC - WmtSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMC2 or Transmembrane Channel-like 2 is a protein that serves as a component of mechanotransduction channels. It has a mass of approximately 104 kDa. TMC2 is primarily expressed in sensory hair cells of the inner ear playing a critical mechanical function in the conversion of sound vibrations into electrical signals. TMC2 operates by forming part of ion channels that are essential to the sensory perception of auditory stimuli.
Biological function summary
TMC2 participates in mechanosensory systems playing an important role in hearing. It forms or associates with ion channel complexes that facilitate the flow of ions into sensory cells which is necessary for initiating receptor potentials. Its presence in sensory hair cells indicates its significant role in the auditory transduction process where it likely interacts with other integral membrane proteins to modulate ion channel activity.
Pathways
Hair cell mechanotransduction involves TMC2 contributing to the mechanotransduction pathway. This pathway is essential for the mechanical-to-electrical sound transduction process. TMC2 likely collaborates with proteins such as TMC1 and other components of the mechanotransduction complex that function in this pathway facilitating ion influx in response to hair bundle deflections caused by sound waves.
Mutations or malfunctions in TMC2 are associated with hearing impairments. Genetic studies indicate its relation to deafness particularly in syndromic and non-syndromic forms of hereditary hearing loss. TMC2's functional relationship with related proteins like TMC1 highlights the critical collaboration between these proteins in maintaining normal auditory function and the risk of auditory disorders when these proteins' functions go awry.