Abcam, ab200348, Anti-RCAS1 antibody [EPR16568]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RCAS1 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16568,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RCAS1 also known as Receptor-binding Cancer Antigen expressed on SiSo cells or Estrogen Receptor Binding Fragment Associated Gene 9 (EBAG9) is a membrane-bound protein with an approximate mass of 32 kDa. It is widely expressed in various tissues including the reproductive system lungs and liver. This protein acts mechanically as a ligand for the RCAS1 receptor facilitating cell-to-cell communication through binding.
Biological function summary
RCAS1 plays a significant role in immune modulation by influencing cell death and immune response. Researchers have not classified it as being a part of any known protein complex. This protein helps regulate the immune system's ability to recognize and respond to abnormal or cancerous cells. It contributes to creating an immune-suppressive microenvironment favoring tumor growth by inhibiting the function of natural killer cells and cytotoxic T lymphocytes.
Pathways
RCAS1's functions intersect with important processes in cellular immune regulation and apoptosis. One of the major pathways involves the Fas signaling pathway where RCAS1 interacts with Fas-related proteins affecting apoptotic cell death. Through this pathway it modulates immune escape mechanisms employed by tumor cells. RCAS1 also correlates with pathways linked to inflammatory responses including its interaction with cytokines such as interferon-gamma.
RCAS1 has significant implications in oncology particularly in various cancers like breast and cervical cancer. Its expression level often shows correlation with tumor aggressiveness and poor prognosis. RCAS1's expression may engage other proteins such as progesterone receptors impacting hormone-related pathways in breast cancer. Additionally the protein's role in immune suppression indicates its potential involvement in immune escape by tumors which makes it a focus of study in cancer immunotherapy.