Abcam, ab200571, Anti-HN1L/L11 antibody

Size: 100µL
Rabbit Polyclonal HN1L/L11 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human JPT2 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human JPT2 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q9H910

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HN1L/L11 protein also known as Hematological and Neurological Expressed 1-Like has a molecular weight of approximately 19 kDa. It is expressed in various tissues including the liver and brain. Mechanically HN1L/L11 is involved in the regulation of cellular growth and proliferation although the exact mechanisms remain under investigation. Researchers often focus on its potential role in modulating gene expression and supporting cellular stress responses.
Biological function summary
HN1L/L11 plays a part in critical cellular functions that support homeostasis. This protein operates within cellular complexes that regulate transcription processes and it may interact with molecular machinery involved in stress adaptation. HN1L/L11's involvement in these essential cellular activities indicates its potential broader impact on maintaining cell survival and integrity in fluctuating environments.
Pathways
HN1L/L11 plays a role in signaling pathways linked to stress response and apoptosis regulation. Notably it is associated with the MAPK and the JAK/STAT pathways which are pivotal in cell survival and differentiation. Through these pathways HN1L/L11 shows interaction with other proteins such as JAK2 and STAT5 all contributing to the orchestration of cellular defense mechanisms under stress conditions.
Researchers have linked HN1L/L11 to various cancer types and neurodegenerative disorders. In cancer the protein's regulation of cell growth pathways implicates its potential role in tumor development and progression often in connection with proteins like p53. In neurodegenerative conditions aberrant expression or function of HN1L/L11 may contribute to neuronal stress and degeneration suggesting it could serve as a biomarker or therapeutic target in such diseases.