Abcam, ab200578, Anti-TBC1D9B antibody - C-terminal

Size: 100µL
Rabbit Polyclonal TBC1D9B antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TBC1D9B aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TBC1D9B aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q66K14

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBC1D9B also known as TBC domain family member 9B is a protein characterized by its role as a GTPase-activating protein for Rab family proteins. It has a molecular mass of approximately 145 kDa. TBC1D9B is expressed widely in human tissues including but not limited to the heart brain and skeletal muscle. This protein interacts with small GTPases regulating their cycle of activation and inactivation which is important for intracellular trafficking processes.
Biological function summary
TBC1D9B participates in the regulation of endosomal dynamics and autophagy. This protein is part of the broader Rab GTPase network influencing vesicular transport and membrane fusion events within the cell. In various tissues TBC1D9B modulates cellular functions such as receptor recycling and protein degradation thereby maintaining cellular homeostasis. The protein's role in endosomal transport is particularly important in neurons where it impacts synaptic vesicle cycling.
Pathways
Several intracellular trafficking pathways engage TBC1D9B. It plays a significant role in the insulin signaling pathway and the endocytic pathway. By interacting with pathways such as these TBC1D9B influences the proper functioning of Rab GTPases notably Rab11. This association is vital for controlling endosomal sorting and recycling processes that are instrumental in various cellular activities like nutrient uptake and signaling cascades linked with cell growth and metabolism.
Certain pathologies demonstrate a connection with TBC1D9B. Alterations in its function have been implicated in diabetes due to the protein's influence on insulin action and glucose regulation. Additionally abnormal activity of TBC1D9B links to neurodegenerative conditions given its critical role in neural trafficking processes. The relationship between TBC1D9B and Rab GTPases like Rab11 underlines its importance in the pathophysiology of these disorders influencing disease progression through impaired vesicular transport.