Abcam, ab201060, Anti-beta Amyloid 1-42 antibody [mOC64]

Size: 20µL / 100µL / 1mL
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) is a rabbit monoclonal antibody detecting beta Amyloid 1-42 in IHC-P, IHC-Fr, Dot Blot . Suitable for Human, Mouse, Rat . - Over 80 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:mOC64,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IHC-FrFl, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody recognizes monomeric, oligomeric and fibrillar forms of beta Amyloid 1-42 peptide and reacts weakly with beta Amyloid 1-40.

Product details:
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, IHC-FrFl, IHC-P in human, mouse, rat samples.
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) has been cited over 82 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) has 8 independent reviews from customers.
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060) specifically detects beta Amyloid 1-42 (UniProt ID: P05067; Molecular weight: 85kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone mOC64 -
ab271968
Antibody clone mOC64 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 568 (
ab224025
ab224026
ab300742
ab302544
ab302803
This antibody was developed as part of a collaboration between Abcam and Professor Charles Glabe, UC Irvine.
mOC64 immunoreactivity maps to residues 3-6 (EFRH) of Aß. It does not recognize pyproglytaminylated Aß at position 3 (Aß3(pE)–42) (Nussbaum et al. 2012, PMID: 22660329 and Hatami et al. 2014, PMID: 25281743).
For further information on the immunogen, please refer to Hatami et al. 2014, 25281743 and Kayed et al. 2007, PMID: 17897471.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Amyloid 1-42 often referred to as Abeta 42 or amyloid beta 1-42 is a peptide derived from the amyloid precursor protein (APP). This peptide consists of 42 amino acids and has a molecular weight of approximately 4.5 kDa. It is predominantly found in the brain especially within regions associated with memory and cognitive function. Beta amyloid 1-42 is a product of enzymatic cleavage by beta and gamma secretases from the larger APP molecule. Due to its aggregation-prone nature beta amyloid 1-42 is a focus in neuroscience research particularly concerning the formation of amyloid plaques.
Biological function summary
Amyloid beta 1-42 plays a central role in synaptic activity and neuronal health. While not inherently pathogenic its tendency to aggregate forms oligomers and fibrils which become toxic to neurons. This peptide contributes to synaptic dysfunction and neuronal cell death and is a major component of extracellular amyloid plaques found in brain tissue. Within the cellular environment amyloid beta 1-42 can interact with receptors membrane lipids and intracellular signaling mechanisms thereby affecting neuronal cell function.
Pathways
Amyloid beta 1-42 is important in the amyloidogenic pathway which is one of the critical components in APP processing. The pathway includes proteolytic enzymes like beta secretase (BACE1) and gamma secretase where misregulation may lead to excessive production or deposition of amyloid beta peptides. Another related pathway is the tau protein phosphorylation pathway which indirectly interacts with amyloid beta 1-42 due to shared signaling intermediates impacting tau stabilization and microtubule assembly in neurons.
Amyloid beta 1-42 plays a pivotal role in Alzheimer's disease a prevalent neurodegenerative disorder. The excessive accumulation of beta amyloid in the form of plaques is a hallmark of the disease contributing to cognitive decline. Also it has links to cerebral amyloid angiopathy where it deposits in the walls of blood vessels of the central nervous system. Both conditions may involve interactions with tau protein another pathological feature of Alzheimer's disease which undergoes hyperphosphorylation leading to neurofibrillary tangles formation.