Abcam, ab201206, Anti-LEMD1 antibody

Size: 100µg
Rabbit Polyclonal LEMD1 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LEMD1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LEMD1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q68G75

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LEMD1 also known as LEM domain containing protein 1 is a protein associated with the inner nuclear membrane. The protein weighs approximately 43 kDa. It expresses predominantly in testicular tissue and some cancers. LEMD1 contains the LEM domain known for its involvement in chromatin organization and nuclear structure interactions and plays a mechanical role in maintaining nuclear integrity and possibly gene regulation.
Biological function summary
LEMD1 participates in nuclear architecture through its role in forming the inner nuclear membrane structure. It is a component of the nuclear lamina a fibrous network inside the nucleus that provides structural support. LEMD1 interacts with other nuclear membrane proteins and chromatin suggesting its involvement in maintaining chromatin stability and epigenetic regulation. Its function in nuclear dynamics indicates an important role in cellular processes like cell division and differentiation.
Pathways
LEMD1 integrates into mechanisms involving nuclear envelope dynamics and chromatin remodeling. It plays a role in the cellular process pathway specifically linked to the regulation of nuclear assembly and disassembly. LEMD1 associates with proteins such as emerin and LAP2 which are also integral to nuclear membrane functions. It supports the proper execution of key biological processes including gene expression and DNA replication by maintaining nuclear structural integrity.
LEMD1 shows relevance in certain cancers such as prostate cancer. Alterations in LEMD1 expression associate with tumorigenic processes indicating its potential role as a biomarker for cancer progression. In cancer its connection to nuclear structure disruptions relates it to proteins like lamin A/C and emerin which also play roles in nuclear stability and have implications in oncogenic transformations. These associations highlight the potential impact of nuclear envelope components in cancer biology.