Abcam, ab201691, Anti-Gemin 5 antibody [EPR17841]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Gemin 5 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17841,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gemin 5 also known as GEMIN5 is a multi-functional RNA-binding protein functioning critically in several cellular mechanisms. It has a mass of approximately 170 kDa. Gemin 5 expresses in various tissues highlighting its diverse roles in cellular activities. One of its primary mechanical roles involves the recognition and binding of snRNA which is necessary for the spliceosomal snRNP assembly. It interacts with other proteins within the SMN complex to exert its function.
Biological function summary
Gemin 5 plays an important role in RNA processing pathways and is integral to the formation and functioning of the SMN complex. This complex involves several related proteins including Gemin 2 Gemin 3 and SMN1 and is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs). Gemin 5 possesses specific domains that allow the binding to snRNA facilitating the assembly of spliceosomal units which are critical for the splicing of pre-mRNA into mature mRNA.
Pathways
Gemin 5's involvement in spliceosomal snRNP assembly places it within the RNA processing and gene expression regulatory pathways. Its interaction with SMN1 and Gemin 3 positions it as an important component in these pathways specifically influencing the splicing pathway. The assembly of snRNPs and subsequent influencing of RNA splicing illustrate Gemin 5's role in maintaining gene expression fidelity which is pivotal for cellular function and homeostasis.
Gemin 5's dysregulation or malfunction associates significantly with spinal muscular atrophy (SMA) and certain neurodegenerative conditions. This association mainly arises through its interaction with SMN1 which when mutated or deficient results in SMA due to impaired snRNP assembly and subsequent motor neuron degeneration. Additionally potential links exist with neurodegenerative disorders where RNA processing defects are implicated though the full scope of its involvement requires further research.