Abcam, ab202972, Anti-Cytoglobin antibody

Size: 100µL
Rabbit Polyclonal Cytoglobin antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CYGB aa 50-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CYGB aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8WWM9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytoglobin also known as CYGB is a globin protein with a molecular weight of approximately 21 kDa. This protein is part of the vertebrate globin family and exhibits oxygen-binding properties. Cytoglobin is mainly expressed in fibroblasts and is detectable in various tissues including the liver brain and kidney. It functions as an intracellular hemoprotein which allows it to facilitate oxygen transport and storage similar to other globins like hemoglobin and myoglobin.
Biological function summary
This globin plays a role in cellular protective mechanisms. Cytoglobin participates in protecting cells from hypoxic and oxidative stress thereby contributing to oxygen homeostasis. Although it is not part of a known protein complex its ability to bind oxygen and reactive oxygen species indicates its significant role in mitigating cellular damage. By maintaining a balance of oxygen levels inside cells cytoglobin helps preserve cellular integrity under stressful conditions.
Pathways
Cytoglobin interacts in significant biological processes related to oxygen regulation. It is closely involved in the hypoxia response pathway where it aids in adapting cells to low oxygen environments. Cytoglobin operates alongside proteins such as hypoxia-inducible factors (HIFs) which help regulate gene expression in response to oxygen availability. It also plays a role in the oxidative stress response connecting to systems involving antioxidant proteins that help mitigate the effects of reactive oxygen species.
Cytoglobin has links to conditions like cancer and fibrotic diseases. Its role in oxygen regulation and response to hypoxia makes it relevant in tumor biology as tumors often create hypoxic environments that promote cancer progression. Cytoglobin's connection to cancer involves interactions with hypoxia-inducible factors that drive tumor adaptability. Additionally in fibrotic diseases such as liver fibrosis cytoglobin's expression levels correlate with disease severity suggesting it as a marker in fibrosis progression. This relation implies potential interactions with proteins like transforming growth factor-beta (TGF-β) which plays a role in fibrotic tissue development.