Abcam, ab203022, Anti-Thy1.1 antibody

Size: 100µL
Rabbit Polyclonal CD90 / Thy1 antibody. Suitable for IHC-P, Flow Cyt and reacts with Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Rat Thy1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Thy1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P01830

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thy1.1 also known as CD90 is a cell surface glycoprotein with a mass of approximately 25-35 kDa. This protein is expressed on a variety of cells including T cells stem cells neurons and fibroblasts. Thy1.1 is important in cell-cell and cell-matrix interactions playing a role in cell adhesion and signaling. It is an important marker used to identify different cell populations especially in murine models. Researchers often study Thy1.1 for its role in immunology and neuroscience due to its widespread expression across different tissues.
Biological function summary
The functions of Thy1.1 involve cell communication and signal transduction. Thy1.1 does not form a known complex but interacts with other molecules to influence the cellular environment. It is involved in processes such as apoptosis inflammation and fibrosis. The protein facilitates cell activation and differentiation by interacting with integrins and other surface molecules further affecting cellular responses.
Pathways
Thy1.1 substantially participates in signaling pathways such as the T-cell receptor (TCR) signaling pathway and fibrosis-related pathways. In the TCR signaling pathway Thy1.1 modulates T cell activation and proliferation. Within fibrosis Thy1.1 involvement affects extracellular matrix regulation and fibrosis progression. It associates with proteins such as integrins and fibronectin which are important in these pathways contributing to diverse cellular outcomes.
Thy1.1 shows connections to conditions like fibrosis and multiple sclerosis. In fibrosis Thy1.1 plays a role in the regulation of extracellular matrix deposition affecting tissue remodeling and repair. It interacts with proteins involved in fibrosis signaling such as transforming growth factor-beta (TGF-β). In the context of multiple sclerosis Thy1.1 expression impacts immune cell functions potentially influencing disease progression. Researchers study these associations to explore therapeutic strategies targeting Thy1.1-related pathways.