Abcam, ab203102, Anti-ADAMTS12 antibody

Size: 100µL
Rabbit Polyclonal ADAMTS12 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS12 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADAMTS12 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P58397

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAMTS12 also recognized as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 12 is a member of the ADAMTS family. It is a secreted enzyme with a mass of approximately 204 kDa. This protease is involved in extracellular matrix remodelling. The expression of ADAMTS12 occurs mainly in placental tissue and at lower levels in various other tissues including the lung and heart. It plays a role in processing protein substrates in the extracellular environment.
Biological function summary
The interactions with other matrix components allow ADAMTS12 to mediate matrix organization and degradation. It does not form part of a larger protein complex on its own but interacts with extracellular matrix proteins like aggrecan and versican. These interactions facilitate the breakdown of large proteoglycans aiding tissue morphogenesis and repair.
Pathways
ADAMTS12 participates in the extracellular matrix organization and degradation pathways. These pathways involve proteins such as aggrecanase and versicanase which ADAMTS12 closely relates to through its proteolytic activity. It plays a significant role in matrix remodelling which is essential for cellular migration and differentiation processes.
Alterations in ADAMTS12 expression link to osteoarthritis and cancer. In osteoarthritis increased ADAMTS12 activity contributes to cartilage degradation. In cancer its expression modifies cellular environments influencing tumor progression. It also interacts with matrix proteins like aggrecan in osteoarthritis and demonstrates associations with cancer-related proteins contributing to disease pathology.