Abcam, ab203205, Anti-SLC10A2/ASBT antibody

Size: 100µL
Rabbit Polyclonal SLC10A2/ASBT antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human SLC10A2 aa 150-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC10A2 aa 150-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q12908

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SLC10A2 also known as the apical sodium-dependent bile acid transporter (ASBT) functions as a sodium/bile acid symporter. It facilitates the uptake of bile acids from the intestinal lumen into enterocytes. SLC10A2 has a mass of about 48 kDa and is highly expressed in the ileal section of the small intestine. This transporter is important in the enterohepatic circulation of bile acids. By importing bile acids SLC10A2 aids in maintaining the bile acid pool and promotes fat digestion and absorption.
Biological function summary
SLC10A2 assists in the absorption and recycling of bile acids to help maintain liver function and lipid metabolism. Although not part of a larger protein complex it tightly works with other transporters to ensure efficient bile acid retrieval. The action of this transporter supports energy balance and nutrient absorption in the body providing a mechanistic link between nutrient availability and metabolic regulation.
Pathways
SLC10A2 plays an essential role in the enterohepatic circulation of bile acids. This pathway reconciles bile acid reabsorption in the intestine with their secretion by the liver. The transporter works in conjunction with other proteins like FXR (Farnesoid X Receptor) and NTCP (SLC10A1) in this pathway to regulate bile acid concentrations impacting cholesterol and lipid homeostasis.
Dysfunctions in SLC10A2 correlate with bile acid malabsorption which can lead to conditions such as chronic diarrhea and Crohn's disease. The Bile Acid Binding Protein (BABP) is related to SLC10A2 in these disorders as it helps solubilize bile acids in the intestinal cells. Proper functioning of SLC10A2 is essential to avoid these disorders and support normal gastrointestinal health.