Abcam, ab204151, Recombinant human SNRK protein (Active)

Size: 5µg / 10µg
Recombinant human SNRK protein (Active) is a Human Full Length protein, in the 1 to 765 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>80% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific activity is 16 nmol/min/mg.,
Accession:Q9NRH2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNRK also known as SNF-related kinase is a serine/threonine protein kinase with a molecular mass of approximately 80 kDa. It is part of the AMPK-related kinases family. This kinase is expressed in a wide range of tissues including heart muscle and adipose tissue. SNRK plays a role in various cellular processes by phosphorylating target proteins influencing their activity and function in the cell.
Biological function summary
Through phosphorylation SNRK controls energy balance and cellular stress responses. It does not function as part of a large protein complex but can interact with other proteins to modulate metabolic processes. SNRK contributes to regulating cell growth apoptosis and metabolism. It has a significant role in maintaining energy homeostasis and responding to nutrient availability potentially affecting metabolic syndrome.
Pathways
SNRK participates in energy-sensing pathways. It plays an important role alongside AMP-activated protein kinase (AMPK) involved in response to cellular energy levels. SNRK is also linked to the insulin signaling pathway which regulates glucose metabolism. Its activity impacts downstream targets such as acetyl-CoA carboxylase an important enzyme related to fatty acid metabolism. This indicates SNRK's importance in pathways influencing metabolic health and organism energy status.
SNRK has shown connections to metabolic disorders and cardiovascular diseases. It emerges as a potential player in the development of type 2 diabetes which involves disrupted energy regulation. Similarly in cardiovascular diseases SNRK interacts with proteins such as AMP-activated protein kinase highlighting its role in cardiac function and health. Understanding SNRK's regulation might offer insights into therapeutic strategies for these conditions.