Abcam, ab20424, Anti-DRD4 antibody

Size: 50µL
Rabbit Polyclonal DRD4 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:ICC, ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DRD4 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.P21917,
Specificity:Cross-reactivity:D4 Dopamine Receptor (176-185) 100%D4 Dopamine Receptor 60%D1 Dopamine Receptor (9-21) 0%D1 Dopamine Receptor 0%D2 Dopamine Receptor (272-282) 0%D2 Dopamine Receptor 0%D3 Dopamine Receptor (2-10) 0%D3 Dopamine Receptor 0%D5 Dopamine Receptor (23-35) 0%D5 Dopamine Receptor 0%

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Dopamine Receptor D4 (DRD4) is a protein known for its role as a receptor in the central nervous system. It is part of the dopamine receptor family which plays a critical role in neurotransmission. DRD4 is encoded by the DRD4 gene and has a mass of approximately 48 kDa. This receptor is commonly expressed in the brain particularly in areas such as the prefrontal cortex. It binds dopamine an important neurotransmitter which leads to the activation of intracellular signaling cascades.
Biological function summary
The DRD4 receptor is involved in modulating neuronal excitability and synaptic plasticity. It belongs to the G protein-coupled receptor complex which is essential for transmitting signals across cell membranes. Upon dopamine binding DRD4 inhibits the production of a secondary messenger called cyclic AMP affecting processes like learning memory and attention. It plays a significant role in the reward system influencing behavior and mood.
Pathways
DRD4 interacts with the dopamine signaling pathway which influences several physiological processes including motor control and emotional response. It also plays a part in the regulation of cyclic AMP working closely with proteins such as adenylate cyclase. The DRD4 receptor works within the dopaminergic pathway contributing to a complex network involved in neurological and psychiatric functions.
DRD4 has been linked to attention deficit hyperactivity disorder (ADHD) and schizophrenia. Variations in the DRD4 gene are associated with an increased risk of these conditions. The receptor’s function in dopamine signaling connects it to other proteins like D2 and D3 receptors which also influence these neuropsychiatric disorders. Its involvement in dopamine regulation makes it a potential target for pharmacological treatments aimed at managing symptoms and modifying disease progression.