Abcam, ab204396, Anti-ANKRD10 antibody

Size: 100µL
Rabbit Polyclonal ANKRD10 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Ankyrin repeat domain-containing protein 10 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Ankyrin repeat domain-containing protein 10 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q9NXR5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ANKRD10 protein also known as Ankyrin Repeat Domain 10 is characterized by a series of ankyrin repeat motifs which are protein-protein interaction domains. This protein has a molecular mass of approximately 76 kilodaltons and is expressed in various tissues within the human body with notable presence in the liver brain and testis. The ankyrin repeats suggest that ANKRD10 functions mechanically by interacting with other cellular proteins possibly acting as a scaffold.
Biological function summary
This ankyrin repeat-containing protein contributes significantly to cellular processes such as signal transduction and cell cycle regulation. ANKRD10 does not operate alone; it forms part of complexes by associating with other proteins to modulate their activities. Its localization and function indicate a role in maintaining the proper functioning of cellular homeostasis which might involve regulating pathways critical for cellular growth and replication.
Pathways
ANKRD10 plays an important role in the TGF-beta signaling pathway which influences processes like cell growth apoptosis and differentiation. This pathway includes other proteins such as SMAD2 and SMAD3 which are known to interact with or be affected by ANKRD10 activity. Additionally ANKRD10's involvement in cellular pathways extends to the regulation of Wnt signaling a pathway critical for development and disease progression wherein proteins like beta-catenin interact with it.
Research indicates that ANKRD10 has associations with cancer and neurodegenerative diseases. In particular dysregulation of ANKRD10 expression has been observed in certain cancer types suggesting a role in tumor progression. Furthermore alterations in this protein might impact the expression of proteins like p53 known for its role in cancer regulation. In neurological contexts aberrations in normal ANKRD10 function might link to neurodegenerative disorders where it could interact with proteins related to neuronal stability.