Abcam, ab204410, Anti-CEP89 antibody

Size: 100µL
Rabbit Polyclonal CEP89 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP89 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP89 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96ST8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP89 also known as Centrosomal Protein 89 weighs around 89 kilodaltons. It functions as a centrosome-associated protein mainly expressed in tissues with rapidly dividing cells such as testis liver and certain brain regions. The protein localizes at the centrosome acting as a scaffold that ensures structural integrity and function during the cell cycle. Its role in centrosome dynamics highlights its importance in cellular division and proliferation processes.
Biological function summary
The protein regulates centrosome maturation and spindle assembly. It forms part of a larger molecular complex that stabilizes centrosomes during mitosis. The protein's interactions within this complex help in the recruitment of other centrosomal elements which are necessary for the proper orientation and separation of chromosomes. These interactions imply its influence in cell cycle progression and cellular integrity.
Pathways
The Centrosomal Protein 89 integrates into critical pathways in cell cycle control and mitotic spindle organization. It aligns closely with the spindle checkpoint pathway which involves proteins like Aurora A and CENP-E that ensure accurate chromosomal segregation. CEP89's influence ensures that these pathways operate smoothly contributing to chromosomal stability and preventing aneuploidy.
CEP89 has connections to disorders like primary microcephaly and some cancer types. Disruption in CEP89's function or expression can lead to abnormal centrosome numbers which affect cell division's fidelity and result in conditions like microcephaly due to improper brain development. In cancer CEP89 may intersect with proteins like p53 where aberrations contribute to unregulated cell proliferation and tumorigenesis.