Abcam, ab204429, Anti-DEPP antibody

Size: 100µL
Rabbit Polyclonal DEPP antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DEPP1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DEPP1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9NTK1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DEPP also known as decidual protein induced by progesterone is a protein involved in various cellular processes. It has a molecular mass of around 23 kDa and is expressed in multiple tissues including the liver heart and skeletal muscles. DEPP is mainly located in the cytoplasm of the cells where it participates in cellular homeostasis by aiding in stress response mechanisms.
Biological function summary
DEPP plays a role in autophagy and apoptosis processes essential for maintaining cellular health by removing damaged organelles and cells. DEPP interacts with other proteins to form complexes that modulate these processes particularly in adaptive responses to environmental stressors like oxidative stress. Its expression changes in response to hormonal influences hinting at its value in reproductive biology and stress adaptation.
Pathways
DEPP integrates into the oxidative stress response and MAPK signaling pathways. These pathways are significant for controlling cell survival and death decisions in diverse environmental conditions. DEPP might interact with related proteins such as ASK1 and JNK playing a role in forwarding stress responses that maintain cellular equilibrium and contribute to organismal health.
DEPP shows potential involvement in neurodegenerative diseases and certain cancers. DEPP's stress response and autophagy roles suggest its influence on Alzheimer's disease pathology where protein aggregates and cellular stress are prevalent. In cancer DEPP can modulate tumor progression through its action on apoptosis-related proteins like Bcl-2 possibly impacting cancer cell survival and metastasis.