Abcam, ab204800, Anti-PN-I antibody

Size: 100µL
Rabbit Polyclonal PN-I antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NT5C3A aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NT5C3A aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H0P0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PN-I commonly known as Protease Nexin I serves as a serine protease inhibitor. It has a molecular mass of approximately 43 kDa. PN-I expression occurs predominantly in the nervous system and various cell types such as fibroblasts and endothelial cells. It regulates the activity of multiple proteases like thrombin urokinase and plasminogen activator. This regulation helps to ensure a balance in protease activity.
Biological function summary
PN-I plays a significant role in maintaining extracellular matrix homeostasis and modulating cellular processes like migration and proliferation. It is part of a complex with proteases that it inhibits forming stable complexes to neutralize their activity. Through its actions PN-I influences cell signaling and tissue remodeling having effects that are essential for physiological processes.
Pathways
PN-I interacts with the fibrinolytic and coagulation pathways. It modulates these pathways by inhibiting enzymes such as thrombin and urokinase impacting processes like blood clot formation and degradation. In the coagulation cascade PN-I effects relate closely to proteins like thrombin affecting blood homeostasis and ensuring a proper response to vascular injury.
PN-I has links to conditions such as thrombosis and tissue fibrosis. Alterations in PN-I expression or function can contribute to pathological states by disrupting protease regulation leading to excessive clot formation or tissue scarring. PN-I interacts with proteins involved in these diseases such as plasminogen activators highlighting its importance in maintaining proteolytic balance in tissues.