Abcam, ab204974, Anti-ZNF471/ERP1 antibody

Size: 100µL
Rabbit Polyclonal ZNF471/ERP1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF471 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF471 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9BX82

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF471 also known as ERP1 is a zinc finger protein that plays a significant mechanical role in cellular processes. It has an approximate molecular weight of around 75 kDa. The protein is expressed in various tissues with a higher presence observed in epithelial tissues. As a zinc finger protein ZNF471 binds to DNA influencing transcriptional regulation. ZNF471/ERP1 is important in maintaining the integrity of gene expression by interacting with specific DNA sequences.
Biological function summary
This zinc finger protein regulates transcription factors and affects gene expression patterns. ZNF471/ERP1 does not exist as part of a larger protein complex allowing it to function more independently. Through its ability to bind DNA it influences the transcriptional activity of multiple key genes involved in cellular growth differentiation and development. It has a significant role in signaling pathways linked to cellular proliferation.
Pathways
ZNF471/ERP1 interacts with transcriptional machinery to regulate the Wnt/β-catenin and TP53 pathways. Within these pathways it plays a regulator role modulating gene expressions necessary for cellular growth and apoptosis. For instance it acts in concert with proteins such as β-catenin and TP53 to either promote or inhibit the transcription of genes depending on the cellular context. These regulatory activities highlight its importance in maintaining cellular homeostasis.
Aberrations in ZNF471/ERP1 expression have associations with cancer specifically colorectal and breast cancer. Dysregulation can lead to uncontrolled cellular proliferation and resistance to apoptosis which are hallmarks of cancer initiation and progression. The protein's interaction with other pivotal proteins such as TP53 and β-catenin in these cancers indicates its therapeutic and diagnostic potential in oncology as researchers explore targeted treatments that may influence this interaction pathway.