Abcam, ab205235, Anti-Mitofusin 2 + Mitofusin 1 antibody [EPR19792]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Mitofusin 2 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Recombinant fragment samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19792,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The mitofusins coordinate mitochondrial network maintenance contributing to the stabilization of cellular energy supply. Mitofusins 1 and 2 participate in forming a complex that ensures mitochondrial integrity and function. By facilitating the fusion of mitochondria these proteins help maintain mitochondrial DNA stability and bioenergetics which are vital for efficient cellular metabolism. These tasks are important for cells that undergo high energy demand thereby ensuring proper ATP production.
Pathways
The mitofusins participate in mitochondrial fusion pathways which are essential for cellular energy metabolism and apoptosis regulation. Mfn1 and Mfn2 along with other proteins like OPA1 ensure mitochondrial structure and function are maintained during these processes. This activity impacts pathways such as the PINK1/Parkin-mediated mitophagy pathway which is important for maintaining healthy mitochondria by eliminating damaged ones.
Mitofusins demonstrate significance in conditions like Charcot-Marie-Tooth disease and mitochondrial dysfunction syndromes. Mutations in Mfn2 link directly to Charcot-Marie-Tooth disease type 2A leading to neuropathy. Additionally impaired mitofusins' function associates with metabolic disorders as mitochondrial dynamics play a role in regulating glucose homeostasis. Understanding their roles further clarifies the interactions with other proteins such as Drp1 contributing to metabolic flexibility and neurodegeneration pathways.
Mitofusin 1 (Mfn1) and Mitofusin 2 (Mfn2) are key components involved in mitochondrial dynamics. These proteins often referred to as mitofusins facilitate the fusion of mitochondrial membranes. The molecular weight of Mfn1 is approximately 84 kDa while Mfn2 is around 86 kDa. Both mitofusins are ubiquitous with expression in diverse tissues particularly in metabolically active cells such as in the heart muscle and brain. Mfn2 is sometimes called 2c-10<3c-9 highlighting its genetic coding. Mitofusin 2 also plays a unique role in interactions beyond membrane fusion.