Abcam, ab205535, Anti-ELOVL5 antibody [EPR17151]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ELOVL5 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17151,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:When testing sample with low protein level, we recommend uploading more amount of lysate, using lower antibody dilution, and using higher sensitivity ECL substrate.We also recommend trying 1%SDS Hot lysis prepare method to get desired Western Blot results.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELOVL5 also known as elongation of very long chain fatty acids protein 5 is an important enzyme involved in the elongation process of fatty acids. It is part of a family that catalyzes the first and rate-limiting step of the elongation cycle adding two carbon units to the acyl chain. ELOVL5 is mainly found in tissues with high lipid metabolism including liver and brain with significant expression also noted in breast tissue. It has a molecular weight of approximately 33.5 kDa.
Biological function summary
ELOVL5 contributes to the metabolism of polyunsaturated fatty acids (PUFAs) which are important components of cell membranes and precursors to signaling molecules. It does not function alone but as part of a multi-enzyme complex that includes desaturases and reductases which enables the efficient synthesis of very long chain fatty acids (VLCFAs). These VLCFAs are critical for maintaining membrane fluidity and for cell signaling processes.
Pathways
ELOVL5 plays a significant role in the biosynthesis pathway of polyunsaturated fatty acids. It works alongside other enzymes such as desaturases to produce long-chain PUFAs from shorter precursor fatty acids. This process is important for the homeostasis of lipid signaling and membrane architecture. ELOVL5 also interacts with ELOVL6 another enzyme within the fatty acid elongation pathway indicating a coordinated interplay in fatty acid metabolism.
Mutations or deficiencies in ELOVL5 can lead to conditions affecting lipid metabolism. One such disorder is spinocerebellar ataxia 38 (SCA38) a neurodegenerative disorder characterized by issues with movement and balance. Research also suggests a link between ELOVL5 and autism spectrum disorders (ASD) though this connection requires further investigation. In these disorders ELOVL5 often interacts with other proteins involved in lipid processing such as fatty acid synthase (FASN) underlying the complex nature of these diseases.