Abcam, ab205617, Anti-IDI1 + IDI2 antibody [EPR17213]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IDI1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17213,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The isopentenyl-diphosphate delta isomerase 1 also known as IDI1 and its paralog IDI2 are enzymes that play an important role in isoprenoid biosynthesis. IDI1 has a molecular weight of approximately 27 kDa. Both IDI1 and IDI2 facilitate the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) two critical intermediates in the mevalonate pathway. These enzymes express widely across different human tissues with notable expression in the liver brain and skeletal muscle.
Biological function summary
IDI1 and IDI2 contribute to the regulation of cholesterol and other sterol biosynthesis by converting linear five-carbon units into branched forms necessary for further pathway reactions. Although not usually part of a larger complex these enzymes directly impact the supply of precursors for the synthesis of essential biomolecules such as steroids dolichols and ubiquinones. This transformation is not only pivotal for maintaining lipid homeostasis but also for facilitating cellular proliferation and differentiation.
Pathways
IDI1 and IDI2 should be considered during discussions on the mevalonate pathway which is an important component of cholesterol synthesis and other essential biomolecule formation pathways. These enzymes interact with other proteins involved in the mevalonate pathway including HMG-CoA reductase which functions upstream of IPP and DMAPP isomerization. IDI1 and IDI2 function vitally to ensure a balance between IPP and DMAPP affecting the synthesis rates of downstream isoprenoids and sterols essential for cell membrane structure and signaling.
Dysregulation of IDI1 and IDI2 has connections to metabolic disorders such as dyslipidemia and certain types of cancer. Altered expression or mutation in these enzymes could disrupt normal cholesterol synthesis potentially contributing to high lipid levels in the blood as seen in dyslipidemia. Furthermore IDI1 connects to oncogenesis possibly contributing to cancer development by aiding in producing isoprenoid derivatives critical for tumor cell proliferation. In these situations the enzymes interact closely with proteins regulating cell growth like Ras through their role in providing necessary lipid modifiers for membrane anchoring and function.