Abcam, ab205948, Anti-ELAC2 antibody

Size: 100µg
Rabbit Polyclonal ELAC2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ELAC2 aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELAC2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q9BQ52

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELAC2 also known as ElaC ribonuclease Z 2 functions as an RNase Z-like enzyme with primary responsibility for processing tRNA molecules by cutting the 3' ends. With a mass of approximately 93 kDa ELAC2 localizes mainly in the nucleus and mitochondria expressing in various human tissues. As an essential component of RNA maturation mechanisms it ensures appropriate RNA synthesis and function within cellular contexts.
Biological function summary
The ELAC2 protein contributes significantly to the maturation and stability of transfer RNAs. It forms a part of the ribonuclease Z (RNase Z) family. ELAC2 activity facilitates the specific removal of 3′ trailer sequences from precursor tRNAs which is important for tRNA functionality and stability. It partners with other proteins to maintain cellular homeostasis and ensure accurate protein translation by processing tRNA precursors effectively.
Pathways
ELAC2 integrates into the broader RNA processing and stability pathways highlighting its significant role in tRNA maturation. Within these pathways ELAC2 interacts with proteins like ELAC1 which share similar catalytic activities albeit with different specificity or localization. These interactions and active participation in RNA processing pathways demonstrate ELAC2’s importance toward maintaining proper cellular function and gene expression regulation.
ELAC2 has associations with prostate cancer and cardiac hypertrophy. In prostate cancer ELAC2 mutations or dysregulation may result in altered RNA processing affecting cellular growth and differentiation. Moreover in cardiac hypertrophy ELAC2 potentially influences myocardial growth by impacting mitochondrial RNA processing. ELAC2-related dysfunctions could therefore offer insight into disease mechanisms alongside proteins like RNASEL which also contribute to these conditions.