Abcam, ab20704, Anti-Mycoplasma pneumoniae antibody

Size: 500µL
Rabbit Polyclonal Mycoplasma pneumoniae antibody. Suitable for IP, ICC/IF and reacts with Mycoplasma pneumoniae samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Mycoplasma pneumoniae protein.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mycoplasma pneumoniae,
Applications:IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Recognises all Mycoplasma pneumoniae antigens. Has not been absorbed and so may react with related microorganisms. Not reactive with bovine or human sera.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.1% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mycoplasma pneumoniae an atypical bacterium lacking a cell wall measures around 0.2 to 0.3 micrometers in size. It is commonly referred to as an "antibiotic-resistant pathogen." Mycoplasma pneumoniae localizes to the respiratory tract where it attaches to epithelial cells using specialized adhesion proteins. It interacts directly with the host cells impairing ciliary function and contributing to respiratory system inflammation. This bacterium has adapted to evade immune responses presenting challenges in treatment due to its resistance to cell wall-targeting antibiotics such as beta-lactams.
Biological function summary
Mycoplasma pneumoniae engages in several cellular processes that contribute to its pathogenesis. It does not appear to be part of a larger protein complex but utilizes a unique set of proteins for adherence and evasion of the immune response. This organism generates reactive oxygen species as byproducts which lead to tissue damage and dysfunction within host tissues. It has evolved mechanisms to modulate host immune reactions allowing it to persist and maintain infections over extended periods.
Pathways
Several associated with Mycoplasma pneumoniae are involved in immune modulation and inflammation. For instance it involves pathways related to cytokine production and epithelial cell signaling. These pathways interact with host proteins such as toll-like receptors augmenting the inflammatory response. Mycoplasma pneumoniae affects these signaling pathways influencing not only the localized respiratory tract environment but potentially broader systemic responses in the host.
Mycoplasma pneumoniae is notably associated with respiratory infections such as atypical pneumonia and it may contribute to the exacerbation of asthma symptoms. During infection it can interact with proteins like interleukin-6 in the inflammatory cascade potentially leading to heightened inflammatory responses. These interactions complicate underlying respiratory conditions making infections more severe and prolonged. Understanding these relationships highlights the need for developing specific anti-Mycoplasma pneumoniae antibodies and diagnostic tools to manage and treat infections effectively.