Abcam, ab20841, Anti-Influenza A Virus antibody

Size: 100µL
Anti-Influenza A Virus antibody (ab20841) is a goat polyclonal antibody detecting Influenza A Virus in IHC-P, ICC/IF . Suitable for Influenza A . - Over 20 publications - Trusted since 2005
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Influenza A,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Influenza A Virus antibody (ab20841) is a goat polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Influenza A samples.
Trusted by the scientific community
Anti-Influenza A Virus (ab20841) was first used in a scientific publication in 2005 and has been cited over 20 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Purification notes->95% pure. Sodium sulfate precipitation and ion-exchange chromatography., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Influenza A virus also known as "flu A" is an important pathogen with a complex life cycle. Mechanically it consists of several proteins including hemagglutinin (HA) and neuraminidase (NA) which facilitate the virus's entry and release from host cells. The mass of the Influenza A virus is not a single value as it is a non-uniform entity composed of different proteins and RNA segments. This virus is mainly expressed in the epithelial cells of the respiratory tract in humans and other organisms. Through antigenic drift and shift the virus changes over time which makes it a significant challenge for public health.
Biological function summary
The Influenza A virus interferes with normal cellular functions. As it enters and replicates within host cells it triggers immune responses that seek to neutralize the virus a process often targeted by flu antibodies and anti-influenza therapies like arbidol 20 mg. The virus can hijack the host cell machinery to produce viral proteins and RNA forming complexes with cellular components to facilitate new virion assembly. This interaction often leads to the production of cytokines and can induce inflammation an important feature of infection by Influenza Type A.
Pathways
The Influenza A virus interacts with cellular pathways involved in endocytosis and RNA replication. It exploits the host cell's clathrin-mediated endocytosis for entry making use of the cellular machinery. In the context of RNA replication the virus's RNA-dependent RNA polymerase complex plays a critical role working alongside host cell proteins to synthesize viral RNA. The virus has well-documented interactions with proteins such as M1 matrix protein and NS1 non-structural protein which modulate both viral replication and interference with host immune responses.
Influenza A is a major cause of seasonal flu outbreaks and pandemics. It can lead to acute respiratory illness and is linked to life-threatening conditions like pneumonia. The virus often coexists in the respiratory system with other pathogens complicating the disease course. Proteins such as neuraminidase are important in its role in spreading the infection and represent targets for anti-flu therapies. The connection between Influenza A virus cytokine responses and severe respiratory conditions makes understanding its interaction with host proteins essential for developing effective treatments.