Abcam, ab210699, Anti-EPHX2 antibody

Size: 200µL
Goat Polyclonal EPHX2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EPHX2 aa 400-450.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EPHX2 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.P34913,
Specificity:ab210699 is expected to recognize all reported isoforms (NP_001970.2; NP_001243411.1; NP_001243412.1). Reported variants represent identical protein: NP_001243413.1, NP_001243411.1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab210699 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPHX2 also known as soluble epoxide hydrolase is an enzyme that plays a mechanical role in the metabolism of epoxides to diols. The enzyme has a molecular mass of approximately 62 kDa. Scientists find EPHX2 primarily in the liver but it also expresses in other tissues such as the heart kidney and vasculature. Its diverse expression across different organs suggests its involvement in various physiological functions.
Biological function summary
Soluble epoxide hydrolase regulates the hydrolysis of epoxides which affects signaling molecules involved in inflammation and vascular tone. EPHX2 does not directly form a complex but functions within cellular environments to modulate lipid signaling pathways. Through its enzymatic action it converts epoxyeicosatrienoic acids (EETs) which helps to control vasodilation and anti-inflammatory responses.
Pathways
The enzyme soluble epoxide hydrolase integrates into the arachidonic acid metabolism pathway and the cytochrome P450 signaling pathway. In these pathways it interacts with metabolites like EETs influencing lipid signaling and inflammatory processes. Additionally its activity relates to proteins such as cyclooxygenase and lipoxygenase which participate in lipid mediator biosynthesis.
EPHX2 has links to cardiovascular diseases and chronic inflammation conditions. Altered EPHX2 activity may contribute to dysregulated blood pressure a factor in hypertension. Moreover the enzyme associates with other proteins like angiotensin-converting enzyme (ACE) which also plays a role in cardiovascular homeostasis. This relationship underlines the potential therapeutic importance of targeting EPHX2 in disease management.