Abcam, ab211448, Anti-NRAMP1 antibody

Size: 200µL
Rabbit Polyclonal NRAMP1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SLC11A1 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC11A1 aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P49279

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NRAMP1 also known as Natural Resistance-Associated Macrophage Protein 1 or SLC11A1 functions as a metal ion transporter in the body and has a mass of approximately 62 kDa. This protein localizes mainly to macrophages and is a part of the membranes of phagosomes. Its role includes the transport of divalent metal ions like iron and manganese across cellular membranes contributing to ion homeostasis in cells.
Biological function summary
NRAMP1 plays a significant role in host defense mechanisms against intracellular pathogens. This protein modulates the immune response by controlling ion concentrations that affect pathogen replication. NRAMP1 does not function in isolation but interacts with the broader immune response network. It influences the innate immune system and is a part of macrophage activation processes that contribute to an organism's defense against infections.
Pathways
NRAMP1 impacts at least two major biological processes: the innate immune response and metal ion homeostasis pathways. It participates in the regulation of ion transport interacting with other proteins like DMT1 (another transporter for divalent metal ions) in balancing metal levels. These interactions are important in preserving cellular iron quotas and preventing oxidative damage through metal-catalyzed reactions.
NRAMP1 has associations with conditions such as tuberculosis and susceptibility to autoimmune diseases. Mutations or variations in NRAMP1 affect the body’s ability to combat Mycobacterium tuberculosis linking it to tuberculosis susceptibility. It also interacts with the protein TLR4 in pathways that influence inflammatory responses and potentially contribute to the development of autoimmune diseases by altering immune responses to prevent overreaction or ineffective clearing of pathogens.