Abcam, ab211450, Anti-RNF125 antibody

Size: 50µL
Rabbit Polyclonal RNF125 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RNF125 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RNF125 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q96EQ8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF125 also known as TRAC-1 is a protein encoded by the RNF125 gene. It belongs to the RING finger family and functions as an E3 ubiquitin-protein ligase which attaches ubiquitin to protein substrates directing them for degradation. RNF125 has a molecular mass of approximately 51 kDa. Researchers observe its expression predominantly in immune-related tissues such as the thymus spleen and peripheral blood leukocytes.
Biological function summary
RNF125 participates in the immune response by modulating the activity and stability of key signaling proteins. It forms part of a regulatory complex that influences immune signaling pathways. RNF125 acts by ubiquitinating proteins like MAVS which play a role in antiviral responses. Through ubiquitination RNF125 helps regulate the balance between activation and suppression of immune reactions ensuring proper immune function.
Pathways
Researchers have identified RNF125 as an important component of the type I interferon signaling pathway and the TLR (Toll-like receptor) pathway. In the type I interferon pathway RNF125 targets proteins such as MAVS and RIG-I playing a role in antiviral defense. Furthermore RNF125 interacts with TRAF6 in the TLR pathway influencing the body's innate immunity and inflammation responses.
RNF125 has connections to immune-related conditions such as autoimmune diseases and chronic viral infections. For example aberrant regulation of RNF125 activity might contribute to systemic lupus erythematosus (SLE) through improper control of MAVS and other immune signaling proteins. Moreover in the context of chronic viral infections RNF125's role in targeting RIG-I for degradation could hinder the immune system's ability to clear persistent viral infections. Understanding these associations provides insights into potential therapeutic approaches.