Abcam, ab211456, Anti-OIF antibody - C-terminal

Size: 200µL
Rabbit Polyclonal OIF antibody. C-terminal. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human OGN aa 200 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OGN aa 200 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P20774

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OIF also known as Ovulation Inducing Factor has a mass of about 14 kDa. It plays an important role in inducing ovulation in certain mammalian species. OIF is expressed in seminal plasma where it serves as a signaling molecule influencing the reproductive cycle. Researchers recognize the impact of OIF on the ovarian follicle where it initiates a cascade of events that lead to ovulation. Its discovery is significant for reproductive biology as it highlights the influence of male factors on female reproductive physiology.
Biological function summary
Ovulation Inducing Factor acts as a signaling molecule that interacts with the female reproductive system to trigger ovulation. It functions as part of a larger biochemical complex that affects the hypothalamus and pituitary gland axis stimulating the secretion of hormones necessary for the release of the egg. The exact interactions and pathways remain an active area of research but the ability of OIF to prompt ovulation positions it as a unique factor among reproductive proteins.
Pathways
There is evidence that Ovulation Inducing Factor is involved in the neuroendocrine pathway for ovulation. OIF interacts with the hypothalamus-pituitary-gonadal axis to initiate ovulation. The presence of other proteins like GnRH and its release is closely tied to the activity of OIF in stimulating the necessary hormonal environment. Furthermore the interplay between OIF and luteinizing hormone (LH) is also explored showing how these elements integrate into the broader signaling cascade essential for ovulation.
Researchers have associated Ovulation Inducing Factor with fertility issues. Disruptions or alterations in the pathway involving OIF can lead to ovulatory disorders impacting fertility in both females and indirectly males. Studies explore its relationship with proteins like FSH and LH which are critical in ovulatory processes. Understanding the role of OIF may advance treatment options for certain infertility problems offering insights into novel therapeutic strategies.