Abcam, ab212838, Anti-Sumo 2 antibody [SPM621] - BSA and Azide free

Size: 100µg
Mouse Monoclonal Sumo 2 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SUMO2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SPM621,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SUMO2.P61956

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-ab212838 was purified from bioreactor concentrate by protein A/G., Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sumo 2 also known as SUMO-2 or SMT3A is a small ubiquitin-like modifier protein with a molecular mass of approximately 11 kDa. It belongs to the SUMO protein family which includes SUMO-1 SUMO-3 and others. Sumo 2 is widely expressed in the nucleus and cytoplasm of eukaryotic cells. It is involved in the post-translational modification process known as SUMOylation where it covalently attaches to specific lysine residues on substrate proteins influencing their activity localization and stability.
Biological function summary
Sumo 2 influences various cellular processes including nuclear-cytosolic transport transcriptional regulation and protein stability. It often forms part of multi-protein complexes showing versatility in regulating cellular responses to stress and maintaining protein homeostasis. Sumo 2's dynamic attachment and detachment from its target proteins allow fine-tuning of cellular pathways reflecting its essential role in managing cellular conditions.
Pathways
Sumo 2 participates in the DNA damage response and the heat shock response pathways. Its involvement helps ensure proper cell cycle progression and stress response through interaction with key proteins like p53 and HSF1. Sumo 2 modification alters the activity of these proteins and others affecting cell survival under stress conditions and facilitating DNA repair mechanisms showing its comprehensive integration in these important cellular processes.
Alterations in Sumo 2 function have links to neurodegenerative diseases and cancer. Abnormal SUMOylation patterns involving Sumo 2 correlate with the progression of Alzheimer's disease and various types of tumors. In these contexts Sumo 2 modulates proteins such as tau and MDM2 which are critical in disease development and progression. Exploring the role of Sumo 2 in these conditions highlights its potential as a target for therapeutic intervention and diagnostic applications.