Abcam, ab214320, Anti-ZnT-3 antibody

Size: 100µL
Rabbit Polyclonal ZnT-3 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC30A3 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC30A3 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q99726

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZnT-3 also known as Znt3 or SLC30A3 is a zinc transporter protein. It facilitates the transport of zinc ions out of the cytoplasm into synaptic vesicles. With a molecular weight of approximately 45 kDa ZnT-3 comprises part of the superfamily of cation diffusion facilitator proteins. This protein is predominantly expressed in the brain particularly within the hippocampus and cerebellum. Its presence in synaptically active regions emphasizes its role in neuronal function.
Biological function summary
The action of ZnT-3 in transporting zinc ions into synaptic vesicles suggests its pivotal function in synaptic transmission and neuronal signaling. Zinc acts as a neuromodulator influencing neurotransmitter release and receptor regulation. ZnT-3 operates independently and it does not form part of larger macromolecular complexes. By regulating zinc ion homeostasis within synaptic vesicles it impacts processes like neurotransmission and neuroplasticity.
Pathways
ZnT-3’s function integrates into the well-known zinc signaling pathways in neural activity. It interacts closely with proteins involved in calcium signaling such as calmodulin. These pathways contribute to synaptic plasticity and cognitive functions like learning and memory. Zinc modulators impact the activity of NMDA receptors through which ZnT-3 participates in modulating synaptic strength and plasticity.
ZnT-3 associates significantly with Alzheimer's disease and epilepsy. Alzheimer's pathology involves disrupted zinc homeostasis highlighting ZnT-3’s role. Alterations in ZnT-3 expression affect amyloid beta accumulation linking it with amyloid precursor protein. Additionally ZnT-3’s influence in synaptic zinc release suggests a relationship with seizure susceptibility in epilepsy where zinc interacts with zinc-binding proteins like metallothioneins affecting neuronal excitability.