Abcam, ab214341, Anti-ERG antibody [EPR3864] - Mouse IgG2b (Chimeric)

Size: 100µL / 1mL
Anti-ERG antibody [EPR3864] - Mouse IgG2b (Chimeric) (ab214341) is a mouse monoclonal antibody detecting ERG in Western Blot, IHC-P . Suitable for Human, Mouse, Rat . - Clone EPR3864 is the most cited clone to ERG - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:EPR3864,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-ERG antibody [EPR3864] - Mouse IgG2b (Chimeric) (ab214341) is a mouse recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.
What is the molecular weight of ERG?
Anti-ERG [EPR3864] - Mouse IgG2b (Chimeric) (ab214341) specifically detects a band for ERG (UniProt: P11308) at a molecular weight of 55kDa.
Other related products
We have a range of other formats of antibody clone [EPR3864] also available for your convenience:
ab92513
, HRP -
ab195514
, Alexa Fluor® 647 -
ab196149
, Alexa Fluor® 488 -
ab196374
, ab214341, Carrier free -
ab214796
, Carrier free -
ab275331
, PE -
ab314261
, APC -
ab315146

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ERG or ETS-related gene is a transcription factor that belongs to the ETS (E-26 transformation specific) family. The ERG protein plays an important role in gene regulation involved in cell growth and differentiation. ERG has a molecular mass of approximately 54 kDa. It is expressed in a variety of tissues including the prostate endothelial cells and hematopoietic cells. Researchers often study ERG protein localization through techniques such as ERG IHC to better understand its expression across different tissues for example in the ERG color sections that highlight specific cellular contexts.
Biological function summary
ERG regulates processes critical for normal cellular functions such as proliferation apoptosis and differentiation. It functions as part of a larger transcriptional regulatory complex and interacts with other proteins to exert its effects on target genes. The ERG protein can affect angiogenesis and limb development through its regulation of vascular endothelial cells. By controlling such important cellular processes ERG influences both normal physiological functions and abnormal conditions when dysregulated.
Pathways
ERG is highly significant in the MAPK/ERK signaling pathway which is involved in cell division and survival. ERG interacts with other signaling proteins such as FLI1 and RUNX1 affecting cellular responses and contributing to the regulation of gene expression essential for development and homeostasis. Within the hematopoietic context ERG participates in the regulation of pathways that maintain stem cell populations making it important for normal blood cell development.
ERG is prominently implicated in prostate cancer where gene fusions involving ERG lead to its overexpression and contribute to malignancy. The abnormal expression of ERG in endothelial cells can also have a role in vascular disorders. ERG's interplay with proteins like TMPRSS2 often seen in gene fusions in prostate cancer underlines its role in oncogenesis. Understanding how ERG regulates these pathways and its interactions with other proteins helps in developing targeted therapies for disorders involving ERG dysregulation.