Abcam, ab215726, Anti-NOD1 antibody [EPR20833]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NOD1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20833,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NOD1 also known as nucleotide-binding oligomerization domain-containing protein 1 is a protein that plays a role as a recognition receptor within the immune system. It has an approximate mass of 103 kDa and is expressed in various tissues including the gastrointestinal tract and epithelial cells. NOD1 functions by detecting specific molecules from bacterial cell walls specifically diaminopimelic acid leading to the activation of immune responses. Through its interaction with bacterial peptidoglycans NOD1 plays an important function in the innate immune defense against pathogens.
Biological function summary
NOD1 is involved in sensing bacterial infections and initiating immune responses. It participates as part of the NOD-like receptor (NLR) family contributing significantly to inflammatory signal transduction. Upon recognition of bacterial components NOD1 triggers signaling cascades that result in the activation of NF-κB leading to the production of pro-inflammatory cytokines. By orchestrating these molecular events NOD1 plays a role in maintaining homeostasis and responding to microbial threats which influences various immune-related processes.
Pathways
NOD1 is integral to the immune signaling pathway involving inflammation and cellular defense. It is associated with the NF-κB signaling pathway and MAPK pathway important in mounting an effective immune response. NOD1 interaction with RIPK2 a kinase protein facilitates downstream activation of these pathways enhancing cytokine production and strengthening the body's defense mechanisms. These pathways enable NOD1 to communicate intracellularly and coordinate responses essential for pathogen clearance.
NOD1 has associations with inflammatory bowel disease (IBD) and asthma. Variants or dysregulations of NOD1 contribute to the susceptibility and pathology of these conditions. Within these disorders NOD1 activity can influence other proteins involved in inflammatory processes such as RIPK2 which acts synergistically to mediate immune responses. Understanding NOD1’s connection to these diseases may lead to therapeutic strategies targeting its signaling cascades to mitigate inflammation and disease progression.