Abcam, ab216620, Anti-GLP2 antibody

Size: 100µL
Rabbit Polyclonal GLP-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GCG aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GCG aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P01275

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glucagon-like peptide 2 (GLP2) also known as glucagon-like peptide-2 and GLP-2 is a peptide that is derived from the proglucagon gene and weighs approximately 4.2 kDa. It is expressed mostly in the intestinal mucosa particularly in the L-cells of the ileum and colon. GLP2 is a 33-amino-acid peptide hormone that is secreted in response to nutrient intake. This peptide is involved in various bodily functions acting mainly in the gastrointestinal tract.
Biological function summary
GLP2 functions to enhance intestinal growth and nutrient absorption. It promotes mucosal epithelial growth increases villus height and reduces gut permeability. These actions make GLP2 critical for maintaining the structural and functional integrity of the gastrointestinal tract. It operates independently and is not part of a larger protein complex but works alongside similar hormones for gut homeostasis.
Pathways
GLP2 is involved in the enteroendocrine signaling pathway. This includes the modulation of the GLP2 receptor which impacts intestinal growth and function. The peptide also shows interplay with proteins like glucagon-like peptide 1 (GLP1) as both affect energy balance and glucose homeostasis although through different mechanisms. GLP2's primary role in enhancing nutrient absorption complements GLP1's efforts in glucose regulation.
GLP2's link to short bowel syndrome and inflammatory bowel disease highlights its therapeutic potential. Its ability to improve intestinal adaptation and reduce inflammation positions GLP2 as a candidate for treating these conditions. Additionally a connection exists with glucagon-like peptide 1 (GLP1) due to their common origin and overlapping pathways although each has distinct functions and disease relevance.