Abcam, ab217032, Anti-FZD3 antibody

Size: 100µL
Rabbit Polyclonal FZD3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human FZD3 aa 150-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FZD3 aa 150-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9NPG1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FZD3 also known as Frizzled-3 is a member of the Frizzled family of G protein-coupled receptor proteins. It has a molecular mass of approximately 76 kDa. FZD3 primarily acts as a receptor for Wnt proteins playing a critical role in signal transduction. These receptors are widely expressed in a variety of tissues including the brain which aids in its multiple functional roles in cellular communication and development.
Biological function summary
FZD3 participates in the regulation of the Wnt signaling pathway a fundamental signaling mechanism important for controlling cell fate proliferation and migration. As a component of the Wnt receptor complex FZD3 interacts with other proteins to initiate a cascade of intracellular events. This process has implications for embryonic development and is essential in maintaining the stem cell niche and tissue homeostasis.
Pathways
It is important to know that FZD3 is an important player in the canonical and non-canonical Wnt signaling pathways. In the canonical pathway it works through beta-catenin-dependent signaling which interacts with proteins like LRP5/6 and Dishevelled. This pathway influences gene expression regulation and plays a vital role in organogenesis and cancerous transformations. FZD3 also engages in the planar cell polarity pathway influencing cytoskeletal and cellular polarity changes.
Alterations in FZD3 expression or mutations connect this protein to several neurological conditions including schizophrenia and Alzheimer's disease. In Alzheimer's FZD3's role in Wnt signaling links it to the amyloid precursor protein pathway associated with amyloid-beta plaque formation. Disrupted FZD3 activity also correlates with impairment in cellular processes regulated by interactions with other proteins in these pathways.