Abcam, ab217362, Anti-CD94 antibody

Size: 100µL
Rabbit Polyclonal CD94 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Klrd1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Klrd1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O54707

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD94 also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1) plays a significant mechanical role in the immune system. This protein forms part of a receptor family involved in natural killer (NK) cell function. CD94 typically assembles on the cell surface as a heterodimer often pairing with NKG2 proteins. Weighing approximately 30 kDa CD94 mainly exhibits expression on NK cells and a subset of T cells where it contributes to immune regulation.
Biological function summary
CD94 is essential in recognizing and binding to non-classical MHC class I molecules when it pairs with NKG2 molecules such as NKG2A or NKG2C. This dimer forms a complex receptor which plays an important role in modulating NK cell activity. Through this receptor complex CD94 influences the immune response by either inhibiting or activating NK cells depending on its NKG2 partner. This regulation helps maintain a balanced immune response preventing excessive activation and autoimmunity.
Pathways
CD94 interacts with the signaling pathways related to the immune response. In particular it is involved in the natural killer cell lectin-like receptor signaling pathway. This pathway manages the activation and inhibition of NK cells integrating signals received through various receptors including CD94/NKG2 dimers. Associated proteins like DAP12 may amplify these signals which ultimately influence cytotoxic activities and cytokine production.
CD94 has notable connections with conditions such as cancer and viral infections. For example certain tumors manipulate CD94 expression on NK cells to evade immune surveillance. Additionally alterations in CD94 and its partner molecules like NKG2A have been observed in viral infections possibly affecting how the immune system responds. Understanding CD94's relationship with these diseases can offer insights into potential therapeutic strategies targeting immune regulation.