Abcam, ab218610, GSK343, histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor

Size: 1mg / 5mg
MW 541.7 Da, Purity >99%. Potent, selective, cell-permeable histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor. Inhibits EZH2 enzymatic activity (IC 50 = 4 nM). Displays 60 fold selectivity for EZH2 over EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. Inhibits H3K27 methylation in HCC1806 cells (IC 50 < 200 nM).
Key facts
CAS number:1346704-33-3,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:541.7 Da,
Molecular formula:C31H39N7O2,
PubChem:71268957,
Nature:Synthetic,
Biochemical name:1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide,
Biological description:Potent, selective, cell-permeable histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor. Inhibits EZH2 enzymatic activity (IC50 = 4 nM). Displays 60 fold selectivity for EZH2 over EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. Inhibits H3K27 methylation in HCC1806 cells (IC50 < 200 nM).,
Canonical smiles:CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C,
InChi:InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40),
InChiKey:ULNXAWLQFZMIHX-UHFFFAOYSA-N,
IUPAC Name:N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2281 GSK343. 2281-5 is the same size as the 5 mg size of ab218610.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions