Abcam, ab219984, Anti-PPP3CB antibody

Size: 100µL
Rabbit Polyclonal PPP3CB antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PPP3CB aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PPP3CB aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P16298

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PPP3CB also known as Calcineurin subunit B type 2 plays an important role in cellular signal transduction. It is a catalytic subunit of the protein phosphatase 3 which requires calcium ions and calmodulin to become activated. PPP3CB is expressed in many tissues with significant levels in the brain and immune cells. Its molecular mass is approximately 59.6 kDa. The protein’s primary mechanical function involves dephosphorylation of serine-threonine residues in proteins which affects various cellular processes.
Biological function summary
PPP3CB is essential in neuronal and immune system function. It is a component of the calcineurin complex composed of a catalytic A subunit and a regulatory B subunit. In neurons it regulates synaptic plasticity and memory functions by modulating neurotransmitter responses. In the immune system it controls T-cell activation and differentiation by mediating the nuclear factor of activated T-cells (NFAT) signaling pathway which is important for the transcription of interleukin-2 and other cytokines.
Pathways
PPP3CB has major involvement in both the calcium signaling and immune response pathways. In the calcium signaling pathway its interaction with calmodulin allows for the activation of downstream signals that influence cellular responses such as growth differentiation and apoptosis. In immune response pathways PPP3CB by controlling NFATc dephosphorylation influences genes critical for immune cell function. It relates closely to proteins like calmodulin and NFAT which play roles in these pathways.
PPP3CB shows a significant link to Alzheimer's disease and autoimmune diseases. Alzheimer's disease involves impaired calcineurin activity which affects synaptic plasticity and memory function. Autoimmune diseases often involve aberrant T-cell activation where PPP3CB plays a modulatory role through NFAT signaling. Dysregulation in this pathway connected to proteins like NFAT can contribute to conditions such as rheumatoid arthritis or systemic lupus erythematosus.