Abcam, ab220153, Anti-EXOC1 antibody

Size: 100µL
Rabbit Polyclonal EXOC1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EXOC1 aa 650-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EXOC1 aa 650-750. The exact immunogen used to generate this antibody is proprietary information.Q9NV70

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXOC1 also known as Exocyst Complex Component 1 is part of the exocyst complex which plays an essential role in vesicle trafficking. The protein works within a large complex that aids in the tethering of secretory vesicles to specific areas of the plasma membrane before fusion. EXOC1 consists of 97 kDa and is the component of the exocyst complex expressed in numerous tissues with high expression in the brain and liver.
Biological function summary
The exocyst complex supports protein and lipid distribution at the cell surface which influences cell signaling growth and differentiation. EXOC1 as a component of this complex contributes to orchestrated membrane dynamics. The exocyst complex includes other proteins such as EXOC3 EXOC4 and SEC10 and together it achieves targeted delivery of vesicles which is necessary for cellular expansion.
Pathways
The exocyst complex including EXOC1 is involved in the exocytosis pathway where it supports the transport of vesicles from the Golgi to the plasma membrane. This protein plays a role alongside small GTPases notably Rho and Rab which regulate vesicular trafficking. EXOC1 associates with the mTOR signaling pathway where it influences cellular growth and metabolism through its role in vesicle targeting.
EXOC1 is linked with conditions such as cancer and diabetes. Its role in vesicle trafficking implicates it in tumor progression where alterations in exocyst complex components disrupt cellular secretion and promote cancerous behaviors. The involvement in the mTOR pathway associates EXOC1 with metabolic disorders such as type 2 diabetes where dysfunctional signaling affects insulin response. Changes in expression levels or mutations in EXOC1 can influence disease states affecting proteins like Rho GTPases within these complexes.