Abcam, ab220229, Anti-SPG21/Maspardin antibody

Size: 100µL
Rabbit Polyclonal SPG21/Maspardin antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPG21 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPG21 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NZD8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPG21 also known as Maspardin is a protein involved in cellular functions with a molecular mass of approximately 48 kDa. It is widely expressed in human tissues notably in the brain and peripheral blood cells. The protein localizes mainly in the cytoplasm and connects with lipid membrane structures. Its mechanical role involves interactions with proteins in the trans-Golgi network and possibly modifies the transport functions within cells.
Biological function summary
SPG21 plays a role in cellular processes such as membrane trafficking and lysosomal function. It is a part of the protein complex involved in sorting and degrading membrane-bound proteins and lipids. Through its interactions with other proteins SPG21 helps maintain cellular homeostasis and protects cells from stress-related damage. It is sometimes associated with lysosome function regulation which is fundamental to cellular waste management.
Pathways
SPG21 interacts with molecules in the lysosomal and Golgi-related pathways. It fits into these pathways by assisting in the transport and breakdown of lysosomal enzymes. These processes are essential for cellular waste processing and lipid metabolism. SPG21 takes part in pathways with proteins like CLN3 and members of the Golgi complex sustaining cellular metabolic balance and facilitating protein recycling.
SPG21 connects closely with hereditary spastic paraplegia (HSP) and neurodegenerative disorders. Mutations in the SPG21 gene lead to a form of HSP known as Mast syndrome characterized by spasticity and neural degradation. SPG21 has potential links with proteins involved in neurodegeneration like SPG7 where dysfunctions can trigger similar symptomatic progressions. Understanding SPG21's role in these diseases aids in targeting therapeutic strategies to mitigate neurological impacts.