Abcam, ab220345, Anti-Synaptopodin 2 antibody

Size: 100µL
Rabbit Polyclonal Synaptopodin 2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SYNPO2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SYNPO2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9UMS6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptopodin 2 also known as Myopodin is an actin-binding protein approximately 125 kDa in mass. This protein exists in various skeletal muscle tissues especially where muscle development and repair occur. Synaptopodin 2 plays a mechanical role by participating in actin filament dynamics affecting cellular structure and movement. It exists in muscle cells and is important for stress fiber formation contributing to the structural integrity of muscle fibers.
Biological function summary
Synaptopodin 2 is important for maintaining muscle function particularly at the cellular level. It interacts with other structural proteins to regulate actomyosin contractility which is essential for muscle contraction and relaxation. This protein is part of larger complexes that involve scaffolding proteins providing a platform for signaling pathways that govern cellular morphology and movement. Its function is essential for maintaining proper muscle alignment and growth impacting muscle health directly.
Pathways
Synaptopodin 2 has strong links to the actin cytoskeleton pathway which is vital for maintaining cell shape and motility. Its interaction with proteins like alpha-actinin and myosin supports the organization of actin filaments and muscle contraction processes. Another important pathway involves the Rho-signaling pathway where Synaptopodin 2 regulates components associated with cytoskeletal reorganization. Through these pathways the protein affects cellular responses to mechanical stress and influences the adaptability of muscle tissues.
Synaptopodin 2 shows associations with muscular dystrophies particularly affecting muscle formation and repair. Aberrations in its function or expression can contribute to improper muscle fiber organization linked to the pathology of muscular diseases. Moreover Synaptopodin 2 interacts with proteins like vinculin which is involved in focal adhesion and any dysregulation might aggravate conditions related to cell adhesion deficiencies. Research continues to explore how Synaptopodin 2-based interventions could mitigate these muscle disorders.